F.A.power point

Acetyl CoA from catabolism of carbohydrates and amino acids is exported from mitochondria via the citrate transport system
Cytosolic NADH also converted to NADPH
Two molecules of ATP are expended for each round of this cyclic pathwayOccurs mainly in liver and adipocytes, in mammary glands during lactation
Occurs in cytoplasm
FA synthesis and degradation occur by two completely separate pathways
When glucose is plentiful, large amounts of acetyl CoA are produced by glycolysis and can be used for fatty acid synthesis
The synthase is dimer with antiparallel subunits.

Each subunit has three domains.
ACP is located in domain 2.
Domain 1 contains transacylases, ketoacyl-ACP synthase (condensing enzyme)
Domain 2 contains acyl carrier protein, ?-ketoacyl reductase, dehydratase, and enoyl reductase.
Domain 3 contains thioesterase activity
The common product of fatty acid synthesis is palmitate (16:0).
Cells contain longer fatty acids and unsaturated fatty acids they are synthesized in the endoplasmic reticulum.
The reactions of elongation are similar to the ones seen with fatty acid synthase (new carbons are added in the form of malonyl CoA).
For the formation of unsaturated fatty acids there are various desaturases catalizing the formation of double bonds.