Systemic Lupus Erythematosus

Systemic Lupus Erythematosus
Lupus history
Lupus is the Latin word for wolf

1st used medically in the 10th century

Described clinically in the 19th century
Butterfly rash in 1845
Arthritis in 1892
Nephritis in 1895 by Osler

Serologic tests become available in the 20th century
LE cell in 1948
Lupus anticoagulant in 1952
ANA in 1954

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Basics
Diagnosis
Pathogenesis
Treatment
The better we know about clinical out come of disease and immune abnormalities we better can fight the disease

Systemic Lupus Erythematosus
Inflammatory multisystem disease
1.5 million cases
Women>Men- 9:1 ratio (90% cases are women)
African Americans>Whites
Onset usually between ages 15 and 45 years, but can occur in childhood or later in life
Highly variable course and prognosis, ranges from mild to life threatening
Characterized by flares and remissions
Associated with characteristic autoantibodies