pharmacology

Drugs Affecting Respiratory System

Diseases
Asthma
COPD
Allergic Rhinitis
Asthma
(clinical symptoms)
•Shortness of breath
•Cough
•Chest tightness
•Wheezing
•Rapid respiration
pathophysiology
•Inflammation of bronchial wall
•Increase mucus secretion
•bronchoconstriction
Drugs therapy
1-?-adrenergic agonist
2-corticosteriods
3-lukotrienes modifiers
4-cromolyn
5-cholinergic antagonist
6- theophylline
7-omalizumab
?2- adrenergic agonist
Albuterol
Levalbuterol
Formeterol
Salmeterol
Side effects
Tremor
Tachycardia
Hyperglycemia
Hypokalemia
hypomagnesemia
corticosteroids
Prednisone
Methylprednisolone
Beclomethasone
Budesonide
Fluticasone
mometasone
M.O.A
1-decrease inflammatory cells
2-reverse mucosal edema
3-decrease capillary permeability
4-inhibit release of leukotrienes
Side effects
Pharyngeal candidiasis
Osteoporosis
Hypokalemia
Risk of diabetic
Glaucoma
Infections
Hypertension
G.U
Leukotrienes modifier
LTB4
LTC4
LTD4
LTE4
LTC4+LTD4+LTE4 are potent bronchoconstrictor
5-Lipoxygenase found in
Mast cells
Basophil cells
Eosinophil cells
Neutrophil cells