Protein synthesis inhibitors

Protein synthesis inhibitors: static
Tetracyclines:
Tetracycline, minocycline, Doxycycline, Demeclocycline
MOA: static
-bind reversibly to 30S & compete with tRNA for its binding with mRNA-ribosome complex
-G+, G-, protozoa, mycoplasma , chlamydia, spirockets, Cl tetani & prefrengens, cholera, Brucella spp

Kinetic:
- Orally
- Absorption decreased in presence of food
-chelate metal ion (Al, Ca, iron, Mg) in presence of milk and dairy products, antacid and iron preparation .
-bind tissues undergoes calcification( bone, teeth)

SE:
Gastric discomfort (mucosa irritation)
Photo sensitivity (sun burn )
Vestibular disturbances
Discoloration & hypoplasia of teeth
bone deformities ( due to Ca chelating )

Uses:
*Cholera
*Brucellosis
*Pneumonia
*urethritis ,Pelvic inflammatory diseases (due Chlamydia) use doxycycline
*Peptic ulcer (H pylori)
*Acne
*Rocky mountain spotted fever (rickettsia)
(chills& fever, aches in bone & joints)
*Lyme diseases ( spirochetes)
(skin lesion, headache , meningoencephalitis)

Uses:
*Cholera
*Brucellosis
*Pneumonia
*urethritis ,Pelvic inflammatory diseases (due Chlamydia) use doxycycline
*Peptic ulcer (H pylori)
*Acne
*Rocky mountain spotted fever (rickettsia)
(chills& fever, aches in bone & joints)
*Lyme diseases ( spirochetes)
(skin lesion, headache , meningoencephalitis)