Chloramphenicol

Chloramphenicol
- is restricted to life-threatening infections for which no alternatives exist
- static or cidal depending on MO (H influenzae)
- bind to 50S & inhibit trans peptidation
- G+, G- bacteria+ rickettsia+ anaerobs
- oral, i/v, pass BBB
- enzyme inhibitor, secreted in breast milk
-produce bone marrow toxicity

SE:
-GI upset, growth candida albicans
-Anemia:
* Reversible anemia dose related
* Hemolytic in patient with deficiency of G6PD
* Aplastic anemia (may persist after cessation)
- Gray baby syndrom
low capacity to glucuronidation &renal function under develop in neonate also in adult in high dose

SE:
-GI upset, growth candida albicans
-Anemia:
* Reversible anemia dose related
* Hemolytic in patient with deficiency of G6PD
* Aplastic anemia (may persist after cessation)
- Gray baby syndrom
low capacity to glucuronidation &renal function under develop in neonate also in adult in high dose

Clindamycin:
- Same MOA of erythromycin
- Used in abdominal infection and infections due toG+ , streptococcus and anaerobic bacteria


SE:
-Pseudomembranous colitis (due growth of closteridium
( so metronidazol or vancomycin used )
Clindamycin:
- Same MOA of erythromycin
- Used in abdominal infection and infections due toG+ , streptococcus and anaerobic bacteria


SE:
-Pseudomembranous colitis (due growth of closteridium
( so metronidazol or vancomycin used )
Clindamycin:
- Same MOA of erythromycin
- Used in abdominal infection and infections due toG+ , streptococcus and anaerobic bacteria


SE:
-Pseudomembranous colitis (due growth of closteridium
( so metronidazol or vancomycin used )