Folate synthesis inhibitor

Folate synthesis inhibitor
Required for DNA synthesis


PABA
dihydropetroate synthase Sulfonamide
Dihydrofolate
dihydrofolate reductase Trimethoprim
Tetrahydrofolic acid
Sulfonamide static
sulfadiazine , Silver sulfadiazine, sulfasalazine, sulfamethoxazole , Mafenid
-compete with PABA for dihydropetroate synthase so inhibit dihydrofolic acid
-against nocardia, enterobacteriaceae in UTI
-Sulfadiazine + pyrimethamine =toxoplasmosis
-sulfadoxine + pyrimethamine =malaria
- Bind to plasma Protein
-Given orally (except Sulfasalazine)
-i/v used in patient unable to taken oral preparation
-Silver sulfadiazine used in burning with sepsis
-Mafenid used in burn (but pain full)
-Pass CSF, placenta
SE:
1- Crystal urea due to acidity of urine
2-Hypersensitivity
3-Hemolytic anemia in G-6-PD deficiency

- Bind to plasma Protein
-Given orally (except Sulfasalazine)
-i/v used in patient unable to taken oral preparation
-Silver sulfadiazine used in burning with sepsis
-Mafenid used in burn (but pain full)
-Pass CSF, placenta
SE:
1- Crystal urea due to acidity of urine
2-Hypersensitivity
3-Hemolytic anemia in G-6-PD deficiency
- Bind to plasma Protein
-Given orally (except Sulfasalazine)
-i/v used in patient unable to taken oral preparation
-Silver sulfadiazine used in burning with sepsis
-Mafenid used in burn (but pain full)
-Pass CSF, placenta
SE:
1- Crystal urea due to acidity of urine
2-Hypersensitivity
3-Hemolytic anemia in G-6-PD deficiency

- Bind to plasma Protein
-Given orally (except Sulfasalazine)
-i/v used in patient unable to taken oral preparation
-Silver sulfadiazine used in burning with sepsis
-Mafenid used in burn (but pain full)
-Pass CSF, placenta
SE:
1- Crystal urea due to acidity of urine
2-Hypersensitivity
3-Hemolytic anemia in G-6-PD deficiency

- Bind to plasma Protein
-Given orally (except Sulfasalazine)
-i/v used in patient unable to taken oral preparation
-Silver sulfadiazine used in burning with sepsis
-Mafenid used in burn (but pain full)
-Pass CSF, placenta
SE:
1- Crystal urea due to acidity of urine
2-Hypersensitivity
3-Hemolytic anemia in G-6-PD deficiency