Nucleic acid synthesis inhibitors

Nucleic acid synthesis inhibitors
Fluoroquinolones (cidal), E inhibitor
1st generation
Nalidixic acid
2nd generation
Ciprofloxacin
Norfloxacin
Ofloxacin
3rd generation
Levofloxacin
4th generation
Moxifloxacin
MOA:
The drug inter cell passively through porins, Inhibit topoisomerase II ( DNA gyrase) so inhibit DNA replication & topoisomerase IV required for cell division (interfer with separation of replicated DNA)

Spectrum:
G- , Pa,Ecoli, , mycobacterium, legionella,
H influenzae, morexella, chlamydia,
MOA:
The drug inter cell passively through porins, Inhibit topoisomerase II ( DNA gyrase) so inhibit DNA replication & topoisomerase IV required for cell division (interfer with separation of replicated DNA)

Spectrum:
G- , Pa,Ecoli, , mycobacterium, legionella,
H influenzae, morexella, chlamydia,
MOA:
The drug inter cell passively through porins, Inhibit topoisomerase II ( DNA gyrase) so inhibit DNA replication & topoisomerase IV required for cell division (interfer with separation of replicated DNA)

Spectrum:
G- , Pa,Ecoli, , mycobacterium, legionella,
H influenzae, morexella, chlamydia,
MOA:
The drug inter cell passively through porins, Inhibit topoisomerase II ( DNA gyrase) so inhibit DNA replication & topoisomerase IV required for cell division (interfer with separation of replicated DNA)

Spectrum:
G- , Pa,Ecoli, , mycobacterium, legionella,
H influenzae, morexella, chlamydia,
MOA:
The drug inter cell passively through porins, Inhibit topoisomerase II ( DNA gyrase) so inhibit DNA replication & topoisomerase IV required for cell division (interfer with separation of replicated DNA)

Spectrum:
G- , Pa,Ecoli, , mycobacterium, legionella,
H influenzae, morexella, chlamydia,