immunodeficiency

Microbiology/Immunology lect.10
Dr.Mohammed A.K.AL-SA ADI
Immunodeficiency
Immunodeficiency is the failure of the immune system to protect against disease or malignancy. Two types:
A-Primary Immunodeficiency is caused by genetic or developmental defects in the immune system. These defects are present at birth but may show up later on in life.
B-Secondary or acquired immunodeficiency is the loss of immune function as a result of exposure to disease agents, environmental factors, immunosuppression, or aging.
Deficiency SPECIFIC IMMUNE SYSTEM
There are variety of immunodeficiencies which result from defects in stem cell differentiation and may involve T-cells, B-cells, and/or immunoglobulins . A defect in the early hematopoiesis which involves stem cells results in reticular dysgenesis that leads to general immune defects and subsequent susceptibility to infections. This condition is often fatal but very rare. It can be treated successfully by bone marrow transplantation.