Reactions of fatty acid ?-oxidation

Fatty acids stored in adipose tissue, in form of neutral TAG, serve as the body s major fuel storage. TAGs provide concentrated stores of metabolic energy because they are highly reduced and largely anhydrous. Stored triacylglycerols are first hydrolyzed by lipases to release glycerol and free fatty acids. The yield from complete oxidation of fatty acids is nine kcal/g as compared to four kcal/g of protein or carbohydrate
The main oxidation of fatty acid
? Oxidation
? Oxidation
Quantitatively ? oxidation of fatty acids is the most important pathway which occurs in the mitochondria.
? oxidation of fatty acids occur on the matrix side of the inner mitochondrial membrane. It’s the most important pathway for fatty acid oxidation. In ? oxidation 2 c atoms are cleaved at a time from fatty Acyl CoA molecules starting at the COOH end.
Several enzymes collectively known as fatty acid oxidase are found in the mitochondrial matrix catalyze the oxidation of fatty acyl CoA to acetyl CoA. The initial event in the utilization of fat as an energy source is the hydrolysis of triacylglycerol
This process is initiated by hormone-sensitive lipase (HSL) , which removes a fatty acid from carbon 1 and/or carbon 3 of the TAG.