Wilms tumor

Wilms tumor


Wilms tumor is "a malignant renal tumor of young children, composed of small spindle cells and various other types of tissue, including tubules and, in some cases, structures resembling fetal glomeruli and striated muscle and cartilage; often inherited as an autosomal dominant trait
Pathology
• The typical Wilms tumor consists of blastemal, epithelial, • and stromal eleThe NWTS correlated pathologic specimens with • clinical outcome and divided various histologic The • unfavorable subgroup includes tumors that contain focal • or diffuse elements of anaplastic cells or two other neoplastic • entities considered not to be Wilms tumor variants, • clear cell sarcoma of the kidney and rhabdoid •tumor of the kidney features •into favorable and unfavorable prognostic groupsments in varying proportions
Symptoms and signs
A swelling in the abdomen A non-tender abdominal mass may be felt Elevated body temperature (fever) Hematuria - bloody urine Abnormal urine color Lack of appetite (reduced appetite) Hypertension - high blood pressure Pains in the abdomen - caused by pressure on other organs near the tumor Nausea Constipation Large and distended veins that appear across the abdomen Malaise Vomiting Hemi hypertrophy - enlargement of one side of the