,iBenign Lesions of the Breast (Papillomas

Benign Lesions of the Breast
1-Papillomas
are benign neoplastic papillary growth composed of multiple branching fibrovascular cores, each having a connective tissue axis lined by (luminal and myoepithelial cells).
Growth occurs within a dilated duct. Large duct papillomas are usually solitary and situated in the lactiferous sinuses of the nipple. Small duct papillomas are commonly multiple and located deeper within the ductal system as seen in picture1,2.
Small duct papillomas have been shown to be a component of proliferative breast disease and increase the risk of subsequent carcinoma.

2-Fibroadenoma :
It’s the most common benign lesion found in the breast of woman of all ages but most often in woman under thirty .

Clinically: single mobile lamp in the breast and increased estrogenic activity may play a role in their development .

Macroscopically :the nodule is usually single ,mobile, firm ,white ,1-10 cm in diameter,encapsulated as seen in picture 3.

Microscopically : there is proliferation of both epithelial and stromal components .
Epithelial form glandular structure lined by single layer or multiple layers of cells that are regular and intact basement membrane .

There is two patterns of growth
1-Pericanalicular pattern : rounded duct usually small with stroma surrounded them as seen in picture 4..
2- Intracanalicular pattern : the ducts appear elongated compressed by extensive proliferation of stromal elements.

1-Papillomas
are benign neoplastic papillary growth composed of multiple branching fibrovascular cores, each having a connective tissue axis lined by (luminal and myoepithelial cells).
Growth occurs within a dilated duct. Large duct papillomas are usually solitary and situated in the lactiferous sinuses of the nipple. Small duct papillomas are commonly multiple and located deeper within the ductal system as seen in picture1,2.
Small duct papillomas have been shown to be a component of proliferative breast disease and increase the risk of subsequent carcinoma.

2-Fibroadenoma :
It’s the most common benign lesion found in the breast of woman of all ages but most often in woman under thirty .

Clinically: single mobile lamp in the breast and increased estrogenic activity may play a role in their development .

Macroscopically :the nodule is usually single ,mobile, firm ,white ,1-10 cm in diameter,encapsulated as seen in picture 3.

Microscopically : there is proliferation of both epithelial and stromal components .
Epithelial form glandular structure lined by single layer or multiple layers of cells that are regular and intact basement membrane .

There is two patterns of growth
1-Pericanalicular pattern : rounded duct usually small with stroma surrounded them as seen in picture 4..
2- Intracanalicular pattern : the ducts appear elongated compressed by extensive proliferation of stromal elements.