Immune complex-mediated (Type III) Hypersensitivity

Immune complex-mediated (Type III) Hypersensitivity

Learning objectives: At the end of lecture, The students should be able to:
1-Define immune complex-mediated (Type III) Hypersensitivity.
2-Mention the types of immune complex.
3-Mention the types of antigens that cause immune complex-mediated injury.
4-Enumerate the types of immune complex-mediated disease.
5-Identify the phases of systemic immune complex-mediated disease.
6-Enumerate the factors that influence immune complex deposition.
7- Describe the histopathological features of immune complex injury.
8-Discuss the pathogenesis of local immune complex disease ( Arthus reaction)
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Immune complex-mediated (Type III) Hypersensitivity
-Definition of immune complex-mediated (Type III) hypersensitivity.
-Examples.
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Immune complex
*Types of immune complex
1-Circulating immune complex(e.g. acute serum sickness).
2-In situ immune complex(e.g. form of glomerulonephritis).
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Antigens of immune complex-mediated Hypersensitivity
-Types of antigens:
1- Exogenous antigens(such as foreign protein, bacteria, and viruses).
2-Endogenous antigens (self antigens).

Immune complex-mediated disease
-Types :
1- Generalized(systemic) immune complex disease (such as acute serum
sickness).
2- Local immune complex disease(Arthus reaction) (e.g. glomerulonephritis,
and arthritis).
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