Cell –mediated(Type IV) Hypersensitivity

Cell –mediated(Type IV) Hypersensitivity
Learning objectives: At the end of lecture, the students should
be able to:
1-Define cell-mediated(type IV) hypersensitivity.
2-Define delayed type hypersensitivity,
3-Describe the morphological features of cell-mediated
hypersensitivity.
4-Explain the sequence of celullar events in delayed type
hypersensitivity.
5-Discuss types, sources, actions of cytokines in delayed type
hypersensitivity.
6-Define T cell-mediated cytotoxicity.
7-Explain the mechanisms of T cell-mediated cytotoxicity.

Definition.
-Pattern of immunologic response:
1-variety of intracelullar microbiologic agents {such
as a bacterium [Mycobacterium tuberculosis],
viruses, fungi, protozoa, and parasites.}
2-skin sensitivity to chemical agents.
3-graft rejection.
4-many autoimmune diseases.

Forms of cell-mediated (type IV)
hypersensitivity
-Forms:
1-Delayed type hypersensitivity (CD4+helper T
lymphocytes.
2-T cell-mediated cytotoxicity (CD8+ T cell)
Delayed type hypersensitivity
-Definition.
-Examples(such as tuberculin reaction)
a protein-lipopolysaccarides component of the
tubecle bacillus.
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