Virulence Factors of Medically Important

fungal adhesion,Colonization, dissemination and the ability to survive in hostile environments , and elude the immune response mechanisms of the host.
The host provides conditions for growth that usually differ markedly from the ecological niche that the fungus normally inhabits. In order to survive in this new environment, potential pathogens must withstand high temperatures, hormonal influences and attacks by phagocytes cells of the immune system
C.albican, P. brasiliensis, B. dermatitidis, H. capsulatum and
C. neoformans occurs when the yeast forms have molecules on the cell wall or capsule which permit adhesion and/or dissemination of the fungal cell to other tissues. Fungal adhesion to the host tissues plays a critical role in infection
P. brasiliensis produces an antigen present on the cell wall, glycoprotein gp43, with the capacity to promote binding to laminin. This molecule is involved in adhesion to the basal membrane or to other components of the extracellular matrix, playing a major role in the dissemination of malignant tumors aaa
Thus, in paracoccidioidomycosis, North-American blastomycosis and histoplasmosis, adhesion molecules seem to be associated with the installation, replication and dissemination of the fungus in the host, as well as with the stimulation of the respiratory burst or synthesis of cytokines by the
Cellsphagocytic