Round nucleus

Round nucleus c-
Cytoplasm, some times small azurephilic granules d-
Origin Bone marow in later fetal and post natal life e-
Become immunocompetant out side of the bone marrow 1-
Differentiate into B cells & T cells 2-
Colonize other organs 3-
B Cell Funtions [matures in Bursa in birds f-
Activated by antigen
Differentiates into Plasma cells
Produces antibodies
Produces Memory cells
T Cell Funtions [matures in thymus gland g-
Cell mediated immunity
Binds to foreign cells
Graft rejection
Produces Memory cells
T Helper & Surpressor cells
Lymphoid element h-



Monocytes 5-
a- Nucleus - oval, kidney, horseshoe; chromatine stains lightly, less condensed, 2-3 nucleoi
( Basophilic cytoplasm with azurophilic granules (lysosome b-
Highlt mobile, highly phagocytophilic c-
( Major cell of chronic infections (100 bacteria per cell d-
Moves into the tissues from the blood after a few days, becomes a histiocyte e-
( Mononuclear phagocytic system (reticuloendothelial system 1-
Receptors on the plasma membrane for complement & immunogloublins 2-

Platelets "thrombocytes -
Fragments of megakaryocyte cytoplasm a-
central zone - purple granule, granulomere b-
transparent zone blue stained, hylomere c-
Releases d-
serotonin - constricks blood vessels 1-
thromboplastin - converts prothrombin -> thrombin 2-

thrombosthenin - causes contraction of the clot 3-
Plasma cells.

Plasma cell, also called plasma B cells, plasmocytes, plasmacytes, or effector B cells, are white blood cells that secrete large volumes of antibodies. They are transported by the blood plasma and the lymphatic system. Plasma cells originate in the bone marrow; B cells differentiate into plasma cells that produce antibody molecules closely modeled after the receptors of the precursor B cell. Once released into the blood and lymph, these antibody molecules bind to the target antigen (foreign substance) and initiate its neutralization or destruction .

Role in disease
Plasmacytoma, multiple myeloma, Waldenstr?m macroglobulinemia and plasma cell leukemia are malignant neoplasms ("cancer") of the plasma cells. Multiple myeloma is frequently identified because malignant plasma cells continue producing an antibody, which can be detected as a paraprotein.
Common variable immunodeficiency is thought to be due to a problem in the differentiation from lymphocytes to plasma cells. The result is a low serum antibody level and risk of infections.
Primary amyloidosis (AL) is caused by the deposition of excess immunoglobulin light chains which are secreted from plasma cell.