Bone Marrow and Hematopoiesis

Bone Marrow and Hematopoiesis
Yellow marrow, storage and reserve, rich in adipose (fat) cells 1-
Red marrow rich in RBC, Hematopoiesis 2-
Newborn - all marrow is red
Adults - flat bones (sternum, vertebrae, ribs, clavicles, bones of pelvis, skull
Structure 3-
fixed cells, reticular cells, sinusoidal capillaries, macrophages, adipose cells a-
free cells, RBC & WBC maturation series b-
remain in groups, one cell type predominates, in different phases of development
Formed elements in the blood have a relatively short life span. 4-
5- Their constant disappearance from the blood is balanced by a continual production of new cells (Hematopoiesis).
6- These begin with undifferentiated stem cells and go through the processes of differentiation and mitosis.
The stem cell (hemocytoblast!) or CFU is formed only the bone marrow. 7-
8- The morphology of the developmental stage in the erythrocytic and granulocytic series in the bone marrow is diagramed in color (page xi) and black and white (page 294) of your text book, Basic Histology.

9- Erythrocyctic series [RBC maturation ] = Intermediates in the developement of Red Blood cells (Erythrocytes)
Proerythroblast a-
Basophilic erythroblast b-
Polychromatophilic erythroblast c-
Normoblast d-
Reticulocyte e-
Erythrocyte f-

10- Granulocytic series = Intermediates in the developement of granulocytic White Blood cells
Promyelocyte a-
Metamyelocytes - Neutrophilic Basophilic and Eosinophilic b-
Mature granulocytes. C-

11- Platelet Production = Megakaryoblast (2n, 4n, 8n, 16n, ), develops into Megakaryocyte1
a- (32n) in the bone marrow. Platelets are cytoplasmic fragments of theMegakaryocyte