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Procalcitonin as a Mediator of Chronic Inflammation in Obese Women with PCOS

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 نادية مضر سلمان مرزة 5/30/2011 9:21:29 PM
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Procalcitonin as a Mediator of Chronic Inflammation in Obese Women with PCOS
Dr.Nadia Mudher Al-Hilli, FIBMS (OB/Gyn )
Dr. Haydar Hashim Al-Shalah, FIBMS (Clinical Path)
Babylon University/ College of Medicine/ Department of Obstetrics & Gynecology
Babylon University/ College of Medicine/ Department of Biochemistry
 
 
Background: Polycystic ovary syndrome (PCOS), a common reproductive endocrine condition characterized by hyperandrogenism, chronic anovulation, and obesity. Obesity is associated with a low-grade inflammation of white adipose tissue resulting from chronic activation of the innate immune system and can subsequently lead to insulin resistance, impaired glucose tolerance and even diabetes.  In the last few years, adipose tissue emerged as an important source of proinflammatory mediators including TNF- , IL-6, and procalcitonin.
 
Objective: to investigate procalcitonin as a marker of chronic inflammation in obese women with PCOS.
 
Method: a case control study conducted from January 2010 till July 2010. The study involved 20 women with PCOS & 20 control women matched for age & BMI. Waist to hip ratio was measured & blood was drawn from patients & controls & serum levels of FSH, LH, prolactin, testosterone & procalcitonin were estimated by VIDAS using VIDAS kits provided by Biomerieux (France). Student t test was used to evaluate the difference in serum procalcitonin level between the two groups.
 
Results: compared with control group, patients with PCOS had a high waist to hip ratio (mean 0.95 ± 0.2 versus 0.8 ± 0.13). Serum procalcitonin level was significantly higher in women with PCOS compared to control group (1.43 ± 0.42 ng/mL    Vs 0.19 ± 0.13 ng/mL) P value was < 0.0001. Serum levels of FSH, LH, prolactin & testosterone all were significantly higher in women with PCOS than in the control group (P value < 0.05).
 
Conclusion: The increase in low-grade chronic inflammation in women with PCOS is primarily associated with increased central fat excess. Procalcitonin represents a novel marker of the inflammatory activity of body fat in PCOS.
 

  • وصف الــ Tags لهذا الموضوع
  • procalcitonin, PCOS, chronic inflammation

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